Cramer2016 - Major Depression as a Complex Dynamic System

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Key takeaways

  • Strong connections with symptoms -> vulnerability to develop MDD
    • A strongly connected network is more likely to end up in a depressed state when pushed by external stressors
  • MDD is thought to be a Bistable system where there are two attractor states: depressed and non-depressed
  • Domino analogy: close together or far apart