Farhat2021 - Systematic Review and Meta-Analysis, An Empirical Approach to Defining Treatment Response and Remission in Pediatric Obsessive-Compulsive Disorder §

• Type:#article
• Year read:#read2021
• Subject: OCD Y-BOCS Psychometrics CGI
• Bibtex: @farhat2021
• Bibliography: Farhat, L. C., Vattimo, E. F. Q., Ramakrishnan, D., Levine, J. L. S., Johnson, J. A., Artukoglu, B. B., Landeros-Weisenberger, A., Asbahr, F. R., Cepeda, S. L., Comer, J. S., Fatori, D., Franklin, M. E., Freeman, J. B., Geller, D. A., Grant, P. J., Goodman, W. K., Heyman, I., Ivarsson, T., Lenhard, F., … Bloch, M. H. (2021). Systematic Review and Meta-Analysis: An Empirical Approach to Defining Treatment Response and Remission in Pediatric Obsessive-Compulsive Disorder. Journal of the American Academy of Child & Adolescent Psychiatry, S0890856721018438. https://doi.org/10.1016/j.jaac.2021.05.027

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Example citation §

A meta-analysis found that a ≥35% reduction on the C-YBOCS, and a score of ≤12 best corresponded to treatment response and remission, respectively, defined as a score of 1 or 2 on the CGI-I/CGI-S [@farhat2021].

Key takeaways §

• 42 RCTs, n = 1234
• ROC-curves with AUC and Youden Index as outcome measures
• Treatment response (35% reduction) AUC = 0.89. Sensitivity 83.9, specificity 81.7
• Remission status (12 points or lower) AUC = 0.92. Sensitivity 82.0, specificity 84.6

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It’s very neat that they found exactly the corresponding figures as the adult version in Mataix-Cols2016 - Towards an international expert consensus for defining treatment response, remission, recovery and relapse in obsessive-compulsive disorder