Grotzinger2022 - Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic, and molecular genetic levels of analysis
- Year read:#read2022
- Subject: Genetics
- Bibtex: @grotzinger2022
- Bibliography: Grotzinger, A. D., Mallard, T. T., Akingbuwa, W. A., Ip, H. F., Adams, M. J., Lewis, C. M., McIntosh, A. M., Grove, J., Dalsgaard, S., Lesch, K.-P., Strom, N., Meier, S. M., Mattheisen, M., Børglum, A. D., Mors, O., Breen, G., iPSYCH, Mattheisen, M., Mors, O., … Nivard, M. G. (2022). Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis. Nature Genetics, 54(5), 548–559. https://doi.org/10.1038/s41588-022-01057-4
- Four broad factors: neurodevelopmenta, compulsive, psychotic, internalizing
- In Lee2019 - Genomic Relationships, Novel Loci, and Pleitropic Mechanisms across Eight Psychiatric Disorders they included MDD with SCZ/BIP as mood and psychotic disorders.
- Little added utility of a single dimension, p-factor
Despite moderate-to-high genetic correlations across all 11 disorders, we find little utility of a single dimension of genetic risk across psychiatric disorders either at the level of biobehavioral correlates or at the level of individual variants.
- OCD and AN loads mostly on compulsive disorers category, but tic disorder has influence from neurodevelopmental disorders category too.
Bottom two panels include a p-factor but model was not improved compared to B panel.