Mahjani2021 - The Genetic Architecture of Obsessive-Compulsive Disorder, Contribution of Liability to OCD From Alleles Across the Frequency Spectrum
- Type:#article
- Year read:#read2022
- Subject: OCD Genetics
- Bibtex: @mahjani2021
- Bibliography: Mahjani, B., Klei, L., Mattheisen, M., Halvorsen, M. W., Reichenberg, A., Roeder, K., Pedersen, N. L., Boberg, J., de Schipper, E., Bulik, C. M., Landén, M., Fundín, B., Mataix-Cols, D., Sandin, S., Hultman, C. M., Crowley, J. J., Buxbaum, J. D., Rück, C., Devlin, B., & Grice, D. E. (2021). The Genetic Architecture of Obsessive-Compulsive Disorder: Contribution of Liability to OCD From Alleles Across the Frequency Spectrum. American Journal of Psychiatry, appi.ajp.2021.21010101. https://doi.org/10.1176/appi.ajp.2021.21010101
Example citation
Key takeaways
- n = 2090 Swedish individuals with OCD
- Narrow-sense heritability was 29% (SE = 4%). Common variants (1-5%) accounted for 10% of heritability, so rare variants (<1%) contribute meaningfully to the heritability
- When you look at twin studies the heritability estimates are higher, and this is likely because you get both rare and common variants. In SNP based analyses you only have common variants.
Refs 1, 4, 5, 8-14