Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits
- Year read:#read2021
- Subject: (in brackets, can also bracket keywords in text)
- Bibtex: @marees2021
- Bibliography: Marees, A.T., Smit, D.J.A., Abdellaoui, A. et al. Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits. Nat Hum Behav 5, 1065–1073 (2021). https://doi.org/10.1038/s41562-021-01053-4
There is large genetic overlap between mental disorders, but mental disorders are also correlated with socio-economic status (SES).
One limitation of genetic studies that do not have within-family control (like sibling designs we can use in Sweden) is that the genetic associations to different phenotypes can be inflated when there is confounding by population-level things like SES.
Since SES is also heritable, there might be a genetic overlap between mental disorders and SES.
So they found a very large reduction for ADHD, while bipolar disorder and schizophrenia are virtually the same. Small effect on OCD.
Study 20 on assortative mating, is it the Nordsletten study?