Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls
- Bibtex: @pettersson2018
- Bibliography: Pettersson, E., Lichtenstein, P., Larsson, H., Song, J., Børglum, A. D., Bulik, C. M., … Polderman, T. J. C. (2018). Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls. Psychological Medicine, 1–8. https://doi.org/10.1017/S0033291718002039
- Correlation r = 0.50 between SNP-based heritability and heritability estimated from family-based registries, when leaving out OCD. OCD likely ruined the correlation since the OCD cases in the genetic studies are “multiplex”, i.e. families with particularly high burden and severe cases.
- Family-based heritability estimates were generally larger, meaning that SNP likely does not capture all of the heritability (the rest may come from rare variants for example
- Genetics are most important in ASD, ADHD, Bipolar disorder, Schizophrenia
- Environment more important in Alcohol dependence, Anorexia, Major Depresison, OCD