Rodriguez2013 - Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder, Proof-of-Concept

  • Type:#article
  • Year read:#read2022
  • Subject: OCD ketamine
  • Bibtex: @rodriguez2013
  • Bibliography: Rodriguez, C. I., Kegeles, L. S., Levinson, A., Feng, T., Marcus, S. M., Vermes, D., Flood, P., & Simpson, H. B. (2013). Randomized Controlled Crossover Trial of Ketamine in Obsessive-Compulsive Disorder: Proof-of-Concept. Neuropsychopharmacology, 38(12), 2475–2483.

Example citation

In one double-blind randomized controlled trial (n = 15), unmedicated participants with severe OCD received either ketamine or placebo. One week after the first infusion, 50% of participants receiving ketamine showed a treatment response, compared to none in the placebo group [@rodriguez2013].

Key takeaways

  • RCT, double-blind, n = 15 adult OCD patients with severe OCD.
  • Y-BOCS used. 4 of 8 ,50%, of ketamine patients responded after one week. 0% response in placebo patients.
  • Three main findings:
    • Participants receiving ketamine first showed significant rapid reduction in obsessions during the infusion that persisted until 1-week post-infusion compared with participants receiving placebo first.
    • Half of participants receiving ketamine first met treatment response criteria at 1-week post-infusion.
    • There were significant carryover effects suggesting that ketamine’s effects on OCD symptoms last longer than previously reported.