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den Braber 2016 - Obsessive–compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs

Aug 31, 2023, 1 min read

den Braber 2016 - Obsessive–compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs

  • Type:#article
  • Year read:#read2022
  • Subject: OCD Genetics
  • Bibtex: @denbraber2016
  • Bibliography: den Braber, A., Zilhão, N. R., Fedko, I. O., Hottenga, J.-J., Pool, R., Smit, D. J. A., Cath, D. C., & Boomsma, D. I. (2016). Obsessive–compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs. Transl. Psychiatry, 6(2), e731. https://doi.org/10.1038/tp.2015.223

Example citation

Polygenic risk scores for OCD significantly predict obsessive-compulsive symptoms in the population [@denbraber2016].

Key takeaways

  • n = 6931
  • Heritability of OCS 0.42, SNP-based heritability 14%
  • OCD PRS predicted OCS in their sample

First, in line with previous studies, we estimated the heritability for OCS at 0.42.4 Stability of OCS over a 6-year time period was 0.63, and cross-twin–cross-time correlations were found to be twice as high in MZ compared with DZ/sib pairs, indicating that the observed stability is mainly caused by genetic factors. Bivariate analyses showed a longitudinal genetic correlation of 0.58. Second, polygenic scores based on a GWA analysis of clinical OCD cases significantly predicted OCS in the independent population-based sample.

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